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Figure 4. Temporal distribution of the apicoplast-targeted proteins and P. falciparum proteases,
potential anti-malarial drug candidates.
The expression profiles of all putative plastid targeted genes represented on our microarray are shown (A). The yellow box encompasses a highly synchronized group of genes, which are in-phase with the plastid genome expression. The average expression profile for this in-phase group of genes is shown and includes most of the known apicoplast targeted genes as well as many hypothetical genes. For reference the average expression profile for the plastid genome is shown (dasshed grey line). Proteases represent an attractive target f9or chemotherapeutic development. The broad range of temporal expression for various classes of proteases and their putative functions are displayed (B). HAP: histo-aspartyl protease(plasmepsin III), Clp: caseineolytic protease, sub1,2: subtilisin-like protease 1,2. Download the datasets for this apicoplast phaseogram as tab-delimited text files, compressed into a zip file: Apicoplast phaseogram (136 KB) Download the dataset for the protease phaseogram as a tab-delimited text file: Protease phaseogram (12 KB) |